This sadistic song is about an abusive relationship which the victim finds "irresistible." Bassist Pete Wentz said it reminds him of a scene involving Sex Pistols bassist Sid Vicious and his girlfriend Nancy Spungen in the 1986 biopic Sid & Nancy. "When I think of 'Irresistible' it brings this image to my head, whether it's fictional or real, of Sid and Nancy in an alley, garbage raining down on them in an eternal spiral of romance and poison," he explained. "Sometimes it's hard not to love what can hurt us the most."
Pete Wentz told Kerrang!: "I'm particularly attracted to people that probably have the ability to hurt me, but hopefully they don't."
Initially released as a promotional single for American Beauty/American Psycho in early 2015, the song was re-released in a remixed version later in the year with additional vocals by Demi Lovato.
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