Novocaine is a pain killer used by dentists. In this song, the singer wants someone to soothe the pain in his life and escape from the monotony of daily life.
This was the first single Eels released, and it found international success as the song did well in the UK, where they remain more popular than in their native America.
The song samples Fats Domino's 1961 hits "Let The Four Winds Blow."
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