Bush frontman Gavin Rossdale wrote "Glycerine" about his relationship with his girlfriend at the time, a model named Jasmine Lewis, who is credited as a backup vocalist on the Sixteen Stone album. Rossdale dated her for about five years before their breakup, which was exacerbated by busy schedules that kept them apart. Gavin's next relationship was with Gwen Stefani, whom he met when her band No Doubt was opening for Bush on the Sixteen Stone tour. They got married in 2002.
Glycerine is a chemical used in perfumes and medicines and also to preserve food. The title comes from the explosive applications of glycerine to stabilize nitro. Rossdale said the song was about how love was like a bomb.
This song came together very quickly for Rossdale, who wrote it in his London flat. When he played it for the band, he felt there was something "ancient and mystical" about it. "I was like a conduit," he told Entertainment Weekly in 2017. "Something about it was bigger than anything we were doing."
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