This song finds Lil Wayne and Kendrick Lamar spinning tales of deceptive women in their lives. Weezy tells the story of a deceitful woman who sets her "boyfriend" up for a robbery, while the Compton MC's verse addresses a woman he doesn't trust in a relationship. The women are likened to Leonardo Da Vinci's famous painting of Mona Lisa, whose ambiguous smile can be interpreted as hiding secrets.
The tale of wicked, deceitful women was likely recorded several years before it was included on the Tha Carter V album. This is indicated by the fact that Wayne references the "Black Mamba" nickname for Kobe Bryant, who played his final game in April 2016.
"Mona Lisa" first surfaced in May 2017, when Martin Shkreli leaked a snippet of the track live on Periscope. The disgraced US pharmaceutical businessman had claimed he'd bought the rights to the Tha Carter V album and he could be heard saying, "It's the best song on the damn thing."
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