This song is about fear. It could be fear of fate, fear of the world, fear of being alone, etc. He wants company and someone to "hold his hand" and "help" him. When he asks to be shown "how to fight this," the song may be referring to fate. He is afraid of the idea that he can't control his life and he will have to be part of "God's masterplan."
Tom DeLonge: "This song is about when you die, and you've just realized you died. You're looking at your lady, trying to say goodbye, and you can see her and you know she's there, but she can't see you and it's too late."
The original chorus lyrics were: "Let's dance until I'm gone, I'm here hold on to me, goodbye, I'm leaving."
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