This song is sometimes translated into the artist simply needing sexual release, but it's truly about the sexual frustrations he cannot overcome.
Here's another theory: It could represent the voice inside a rapist's head. "Help me get Away from myself" and "You can have my isolation" implies that after he rapes his victim he's willing to go to jail (isolation). The line, "You can have my absence of faith you can have my everything" means his whole life is gone once in prison. It is basically a song about an obsession that one cannot control.
A remix of this song plays during the opening credits of the movie Se7en starring Brad Pitt, Morgan Freeman, Gwyneth Paltrow, and Kevin Spacey. This version can be found on the CD-single "Closer To God."
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