Jason wrote this for a friend of his who had just been diagnosed with cancer (thus explaining the lyrics, "We will cure this dirty old disease"). The song is about not letting life get you down no matter what happens, and that you shouldn't waste your life worrying all the time, especially if you may not have very long to live.
This song was originally a part of a longer song of Jason's called "The Dreamlife of Rand McNally." You can hear the longer version on Jason Mraz Live (at Java Joe's), as well as on various live bootleg recordings.
Mraz wrote this with the songwriting trio of Lauren Christy, Graham Edwards, and Scott Spock, who are known as The Matrix. They wrote many of Avril Lavigne's hits, including "Complicated" and "Sk8er Boi."
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