This song is about a girl who believes she has a lousy life, so she takes drugs to numb the pain. She tries to save herself from life by using the drugs.
The message of this song seems to be that pills won't make your life better: they can make you act and feel different, but you will never escape the problems you have in your life. In the video, Manson is representing the JFK assassination. After the assassination, Jackie, his wife, was deeply depressed, and anti-depressants couldn't take away what happened.
Samuel Bayer, famous for his work on "Smells Like Teen Spirit," directed the video.
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