This song is about how sexual attractions can become an addiction. Ironically, scientists have proven that sexual experiences or images stimulate glands in the brain to produce endorphins that actually create a natural "high," hence the line "I need a fix in those heroin eyes." This song also explores how lonely people will often chase after a partner in order to fulfill themselves: "Only you entwined could make this orphan feel at home."
Christa Paffgen is better known as Nico, a German model who worked with Andy Warhol and sang with the Velvet Underground. Neither her proper name or stage name appear in the lyrics, but Hollywood icons James Dean and Marilyn Monroe do.
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