"Poison Whiskey" is about the effects of alcoholism, which is a bit ironic since Lynyrd Skynyrd played almost every concert under the influence of alcohol.
Johnny Walker, as mentioned in the lyrics, is a Scotch whiskey that comes in four types: red label (basic), black label (12 year), gold label (18 year), and blue label (very top shelf).
An acoustic version sung by Johnny Van Zant appears on their album Endangered Species.
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