Like many Led Zeppelin songs, this borrows from an old Blues tune, in this case a song of the same name also known as "Jesus Make Up My Dying Bed," which was performed by Blind Willie Johnson in the 1920s. Bob Dylan recorded an adaptation of the song on his first album, which Led Zeppelin used as the basis for their version of "In My Time Of Dying."
The ending was not written when the band started recording the song. They jammed on it and improvised an ending - you can hear drummer John Bonham say at the end: "That's gotta be the one."
This runs 11:06. Excluding their live cuts, it is the longest Zeppelin song.
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