"Wire" is about the dangers of heroin use. U2 stayed mostly drug-free, but they had many friends who became addicted, including Phil Lynott from Thin Lizzy, who died from heroin abuse in 1986. U2 bass player Adam Clayton was arrested in Ireland for marijuana possession in 1989, but the conviction was waived in lieu of a donation to charity.
This was one of the first U2 songs produced by Brian Eno, who had worked with David Bowie and Talking Heads. Eno went on to produce The Joshua Tree and Achtung Baby.
U2 would revisit the theme of heroin abuse later on the album with "Bad" and on The Joshua Tree with "Running To Stand Still."
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