This song is about a depressed, disturbed man who is in a hopeless/useless relationship, where nothing that he does or can do will make a difference. He beats himself up over the problems and tries to make us see that this is how living like that is - depressing and uneasy.
John Nolan answered a question about the meaning of this song on his Formspring account, explaining that Adam Lazzara wrote the lyrics and that they were a reflection of "where he was at the time."
The "Ghost Man" is a term used in wiffleball, dodgeball and sometimes baseball when a small number of players are participating. If a runner reaches third base and it's his time to bat, he'll be replaced at third with a "Ghost Man," meaning an implied runner.
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