Like Loc's other hit "Wild Thing," this was written by Marvin Young, who recorded as Young MC. Both songs have a similar sound and comical lyrics. "Wild Thing" was the first ever Platinum-certified rap single; "Medina" was the second.
In 1959, The Clovers recorded Love Potion #9, and took almost 30 more years before another song about a powerful aphrodisiac became a big hit. In this song, Loc's love potion is the Funky Cold Medina, which is so powerful it even works on dogs. Loc makes it clear that you have to be very careful with the Medina, or it could have unintended consequences, like marriage.
This song contains a soup of samples. The drum break is from "Get Off Your Ass and Jam" by Funkadelic, and the main guitar riff is from "Hot Blooded" by Foreigner. Other samples are "Satisfaction" by The Rolling Stones (when this song is mentioned), "Christine Sixteen" by KISS, "All Right Now" by Free, "You Ain't Seen Nothing Yet" by Bachman-Turner Overdrive.
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