Before this single, The Prodigy mainly used samples for their vocal tracks. However for "Poison," their MC, Maxim, recorded the singing part. The founder of Prodigy Liam Howlett explained to Q magazine March 2008: "(Poison) was a turning point for us. Freestyling over the music. When we did that we thought, 'Why the f--k haven't we done this before."
Howlett added in the same interview: "Everyone was speeding things up, trying to do drum/n/bass. I was trying to do something that was equally as tough but really slow."
"Poison" featured in the 1999 film End Of Days.
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