"Plug in Baby" is about evolution in the wake of modern technology. Speaking to Rock Sound in 2001 about the song's meaning, lead singer and guitarist Matt Bellamy said: "There's the good side and the bad side [to technology]; abandoning all individuality, becoming a collective whole via cables, and genetically engineering bodies that can exist out in space, or the loss of individualism."
Matt Bellamy used a Hugh Manson custom electric guitar, with a built-in Z Vex Fuzz Factory set for the classical-influenced intro riff. The song helped Bellamy establish himself as one of the most innovative guitarists of his generation.
On the show Muse: The Making of Origin of Symmetry, which aired on the UK radio station Xfm, Matthew Bellamy described this song as: "A feeling of not being connected to each other, but we are, and it's a feeling of the mind evolving from the body, but when that happens you just get this yearn to do something physical and feel something sensational."
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