"Medicate" is the first single from AFI's eighth studio album, Crash Love. In a making-of clip for the "Medicate" music video, lead singer Davey Havok explained the song's meaning: "'Medicate' is a song that really touches on the moments of elation that people often experience as a result of very powerful yet fleeting moments, and how it can sometimes turn very dark, very quickly."
AFI played this song live for the first time at Lido in Berlin on August 25, 2009.
Frontman Davey Havok told LA-based radio station KROQ that one of the song's many meanings is, "speaking of the mutability of elation that's based in really powerful, yet fleeting, experiences and those experiences being referred to in a sort of metaphoric way such as medication."
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