The Stones recorded this at Chess studios in Chicago during their first US tour. Many American Blues artists who The Stones admired recorded there.
This is about the pursuit of women on the road. Mick Jagger is the spider and the fly is the girl who gets caught in his web.
The Stones redid this for their 1995 compilation Stripped. In order to reflect their advancing age, the woman who comes on to Jagger in the song was changed from 30 to 50 years old.
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