The opening track on The Black Parade, this song, originally titled "Father," is about the final moments of The Patient as he dies. The Patient is the main character of the album's storyline, and the listeners can hear his ECG monitor beeping, counting down towards his death. In the next song, "Dead!," the ECG is flatlined, to signify... well, death.
The band opened their sets on The Black Parade world tour by wheeling frontman Gerard Way out on a hospital gurney while he sang the first few lines of the song.
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