This Compton track features a hook sung by South African born songstress Candice Pillay and a verse by Eminem. Pillay told MTV News: "If you listen to 'Medicine Man' compared to everything else on the album, it's a very different record. I feel like it's a younger generation's record. Of course, Dre loved it. And the only person who could fit on that record is Em." She added regarding Eminem's verse: "He gave us a plethora of stuff to choose from and then he went back and forth. And then we finally went with the verse that you hear."
Eminem came under fire for his controversial verse, which features lyrics about rape. ("Ain't no one safe from, non-believers there ain't none. I even make the bitches I rape cum") he rhymes. The Detroit native has form for provocative rhymes about sexual assault. He was previously criticized for a scene where he attempts to rape Iggy Azalea on the Bad Meets Evil Shady XV track, "Vegas."
The song title plays on Dr. Dre's name in a similar fashion to another Eminem-featuring cut, "I Need a Doctor."
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