This song has the rather zen message of smiling through whatever problems are happening. Many times the simple act of smiling will increase happiness in yourself or others, and the singer is finding reasons to smile despite his difficulties.
Dennis Hopper and Dean Stockwell are both in the video. They discuss the existence of Gnarls Barkley as if it is a person rather than a band. Pink Floyd would be impressed - their song "Have A Cigar" makes reference to a record executive who asked "which one's Pink?"
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