As the title suggests, this song takes place in a mental institution. The song is about how they take over your life when you're there, and you're "trapped in a nightmare."
The video is set in an insane asylum, with deranged patients running rampant. It's hardly the first time a video used such a scene ("Metal Health" by Quiet Riot comes to mind), but the Anthrax clip is both outrageous and gritty, showing the crazies in fetid conditions. According to press materials from the band, the video was banned by MTV, who believed the clip to be degrading towards the mentally ill.
The song checks in at number 46 on VH1's 100 Greatest Hard Rock Songs.
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