This was originally a #39 hit for Motown artist Brenda Holloway in 1967. Holloway shares writing credit on the song with Berry Gordy, Frank Wilson and Patrice Holloway.
Blood, Sweat & Tears founder and keyboard player Al Kooper came up with the idea to cover this song, but he left the group before they recorded it. His replacement, David Clayton-Thomas, took over and sang lead on this track. Clayton-Thomas explained: "They had tried it with Al Kooper and they weren't happy with the vocals, so they never did record it. Then up at [drummer] Bobby Colomby's place one day, he was playing me a bunch of stuff that they had been considering, and I heard 'You've Made Me So Very Happy.' I said, 'Whoa, who's that? That's Brenda Holloway! I know that song!' So we did the chart and it went into the show, and we played it down at the club, and we ran up in the studio and recorded it."
This was the first of three US #2 songs (also "Spinning Wheel" and "And When I Die") on BS&T's second LP, Blood, Sweat & Tears.
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