This song deals with the placebo effect, meaning that if you think you are taking medicine, you will feel better, even if the medicine contains no active ingredients. In the song, the girl's misery is in her head, and she has the power to feel better.
Jack White explained: "I suppose it is just about this tongue in cheek take on male and female relationships when things are bothering girls about headache medicine. Aspirin, Tylenol and things like that. It's like men can take anything like a sugar pill and it will make their headache go away but there is always some sort of special care for women. It is sort of a metaphor for taking the time to care for someone I guess."
This is Meg White's least favorite song of the band's because she finds the meaning behind the song problematic. She even made Jack White remove some lyrics before agreeing to record the song. In response to this, Jack would tease Meg by changing the lyrics to "Meg, you have no faith in medicine..." when performing it live.
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